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NLRP3 inflammasome activation through heart-brain interaction initiates cardiac inflammation and hypertrophy during pressure overload
Stromal changes in the aged lung induce an emergence from melanoma dormancy
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
PI (3, 4) P2-mediated cytokinetic abscission prevents early senescence and cataract formation
Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis
Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis
Hypothalamic dopamine signaling regulates brown fat thermogenesis
MARK4 controls ischaemic heart failure through microtubule detyrosination
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
Convergent somatic mutations in metabolism genes in chronic liver disease
A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program
Reprogramming roadmap reveals route to human induced trophoblast stem cells
A simple and rapid method for enzymatic synthesis of CRISPR-Cas9 sgRNA libraries
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
A bivalent vaccine containing D614G and BA.1 spike trimer proteins or a BA.1 spike trimer protein booster shows broad neutralizing immunity
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry
The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy