Vectors for Human SIGLEC8

Gene Information

  • Offical Gene Symbol SIGLEC8
  • Species Human (Homo sapiens)
  • Offical Full Name sialic acid binding Ig like lectin 8
  • Other Aliases SAF2; SIGLEC-8; SIGLEC8L
  • Other Desigations sialic acid-binding Ig-like lectin 8; CDw329; SAF-2; sialoadhesin family member 2
  • Gene Type protein-coding
  • 개요
    Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
  • NCBI Gene ID 27181
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human SIGLEC8(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human SIGLEC8 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human SIGLEC8 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human SIGLEC8 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human SIGLEC8 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human SIGLEC8 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human SIGLEC8 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human SIGLEC8 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human SIGLEC8 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human SIGLEC8 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human SIGLEC8 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human SIGLEC8 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human SIGLEC8 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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