Vectors for Human CCL4L2

Gene Information

  • Offical Gene Symbol CCL4L2
  • Species Human (Homo sapiens)
  • Offical Full Name C-C motif chemokine ligand 4 like 2
  • Other Aliases AT744.2; CCL4L; SCYA4L; SCYQ4L2
  • Other Desigations C-C motif chemokine 4-like; MIP-1-beta; chemokine (C-C motif) ligand 4-like 2; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1b2; monocyte adherence-induced protein 5-alpha
  • Gene Type protein-coding
  • 개요
    This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3\' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3\' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014] Annotation information: Note: In NCBI\'s Homo sapiens Annotation Release 106, this GeneID (GeneID:388372) was annotated as the CCL4L2 gene copy of this chemokine (C-C motif) ligand 4-like family member, while highly similar GeneID:9560 was annotated as the CCL4L1 gene copy. However, it has now been determined that these gene copies can be distinguished based on 3\' terminal exon splice site usage, as described in PubMedID:15843566. Genomic sequence analysis at the annotated locations indicates that GeneID:388372 actually represents the CCL4L1 gene copy, while GeneID:9560 represents the CCL4L2 gene copy. The gene symbols have therefore been switched accordingly. The CCL4L1 gene copy is present only on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly, while the CCL4L2 gene copy is present on the primary chromosome 17 assembly (NC_000017.11) and on both the ALT_REF_LOCI_1 and ALT_REF_LOCI_2 alternate haplotypes. [17 Jun 2014]
  • NCBI Gene ID 9560
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human CCL4L2(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human CCL4L2 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human CCL4L2 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human CCL4L2 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human CCL4L2 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human CCL4L2 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human CCL4L2 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human CCL4L2 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human CCL4L2 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human CCL4L2 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human CCL4L2 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human CCL4L2 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human CCL4L2 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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