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  3. Vectors for Human VAV1

Vectors for Human VAV1

Gene Information

  • Offical Gene Symbol VAV1
  • Species Human (Homo sapiens)
  • Offical Full Name vav guanine nucleotide exchange factor 1
  • Other Aliases VAV
  • Other Desigations proto-oncogene vav; vav 1 guanine nucleotide exchange factor; vav 1 oncogene
  • Gene Type protein-coding
  • 개요
    This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
  • NCBI Gene ID 7409
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human VAV1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human VAV1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human VAV1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human VAV1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human VAV1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human VAV1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human VAV1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human VAV1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Human VAV1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Human VAV1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human VAV1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human VAV1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Human VAV1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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