Human RAG2 벡터 - 렌티바이러스, AAV, shRNA & CRISPR I 벡터빌더

Gene Information

Offical Gene Symbol RAG2
Species Human (Homo sapiens)
Offical Full Name recombination activating 2
Other Aliases RAG-2
Other Desigations V(D)J recombination-activating protein 2; recombination activating gene 2
Gene Type protein-coding
개요
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
NCBI Gene ID 5897
RefSeq Transcript
NM_000536.4; NM_001243785.2; NM_001243786.2
RefSeq Protein
NP_000527.2; NP_001230714.1; NP_001230715.1
External Links NCBI | OMIM | Ensembl | HGNC | UCSC Genome Browser View
View ORF sequence of this gene »

Vector Description	Vector Type	Price
Human RAG2 expression regular plasmid vector	Mammalian Gene Expression Vector Guide	From $189
Human RAG2 expression lentivirus vector	Mammalian Gene Expression Lentiviral Vector Guide	From $189
Human RAG2 expression adenovirus vector	Mammalian Gene Expression Adenoviral Vector Guide	From $189
Human RAG2 expression AAV vector	Mammalian Gene Expression AAV Vector Guide	From $189
Human RAG2 expression PiggyBac vector	Mammalian Gene Expression PiggyBac Vector Guide	From $189

Vector Description	Vector Type	Price
Human RAG2 shRNA lentivirus vector	Mammalian shRNA Knockdown Lentiviral Vector Guide	$149	View Vector
Human RAG2 shRNA adenovirus vector	Mammalian shRNA Knockdown Adenoviral Vector Guide	$299	View Vector
Human RAG2 shRNA AAV vector	Mammalian shRNA Knockdown AAV Vector Guide	$149	View Vector
Human RAG2 shRNA PiggyBac vector	Mammalian shRNA Knockdown PiggyBac Vector Guide	$149	View Vector

Vector Description	Vector Type	Price
Human RAG2 CRISPR regular plasmid vector	Mammalian CRISPR Vector (Single gRNA) Guide	$149	View Vector
Human RAG2 CRISPR lentivirus vector	Mammalian CRISPR Lentiviral Vector (Single gRNA) Guide	$149	View Vector
Human RAG2 CRISPR adenovirus vector	Mammalian CRISPR Adenoviral Vector (Single gRNA) Guide	$299	View Vector

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