Vectors for Human LOC109648314

Gene Information

  • Offical Gene Symbol LOC109648314
  • Species Human (Homo sapiens)
  • Offical Full Name -
  • Other Aliases -
  • Other Desigations GATA activator MPRA enhancer 44; GATA motif-containing MPRA enhancer 44; RUNX1 +24 enhancer; RUNX1 intronic hemetopoietic enhancer; massively parallel reporter assay enhancer 44
  • Gene Type biological-region
  • 개요
    This region represents a conserved enhancer element located in a 5\' intron of the runt related transcription factor 1 (RUNX1) gene. The corresponding sequence in mouse drives expression of Runx1 in the hemetopoietic cell lineage. A sub-region of the human element was also validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in K562 erythroleukemia cells. This sub-region contains a conserved motif for a GATA activator, and mutation of the motif results in reduced enhancer activity. This genomic region was shown to have physical interactions with both the RUNX1 P1 and P2 promoters as well as a conserved sequence in intron 5. [provided by RefSeq, Nov 2017]
  • NCBI Gene ID 109648314
  • External Links NCBI UCSC Genome Browser View
No vectors are found in our database for this gene. We may introduce vectors for this gene in the future.

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