Vectors for Human LOC106799843

This genomic region is located in an intron of the CD81 (CD81 molecule) gene on chromosome 11. A subregion can function as an enhancer by reporter assays in human Jurkat T cells. The spatially equivalent or corresponding region in mouse, which is not conserved at the sequence level, can also function as an enhancer in mouse EL4 T cells. The chromatin structure of this region represents a histone acetylation island in human T cells based on the diacetylation of histone H3 at lysines 9 and 14. Two subregions marked by the H3K4me1 histone modification were also shown to be active enhancers by ChIP-STARR-seq in human embryonic stem cells. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]