Vectors for Human LOC106728418

Gene Information

Offical Gene Symbol LOC106728418
Species Human (Homo sapiens)
Offical Full Name -
Other Aliases -
Other Desigations -
Gene Type biological-region
개요
This region encompasses the proximal promoter and upstream regulatory elements of the leptin gene, including an enhancer in placental cells. The placental enhancer is derived from an endogenous retroviral long terminal repeat (LTR), and therefore represents an example of retroelement exaptation. Activity of the promoter is stimulated by hypoxia and insulin. This region is methylated and epigenetically-silenced in tissues that do not express leptin. Naturally-occuring common polymorphisms in this region (e.g. rs7799039; G-2548A) may affect activity of this promoter and correlate with obesity and other health measures. [provided by RefSeq, Jun 2016]
NCBI Gene ID 106728418
External Links NCBI UCSC Genome Browser View
View ORF sequence of this gene »

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