Human HLA-DMB 벡터 - 렌티바이러스, AAV, shRNA & CRISPR I 벡터빌더

Gene Information

Offical Gene Symbol HLA-DMB
Species Human (Homo sapiens)
Offical Full Name major histocompatibility complex, class II, DM beta
Other Aliases D6S221E; RING7
Other Desigations HLA class II histocompatibility antigen, DM beta chain; MHC class II HLA-DMB; MHC class II antigen DMB; MHC class II antigen HLA-DM beta chain; class II histocompatibility antigen, M beta chain; really interesting new gene 7 protein
Gene Type protein-coding
개요
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
NCBI Gene ID 3109
RefSeq Transcript
NM_002118.5
RefSeq Protein
NP_002109.2
External Links NCBI | OMIM | Ensembl | HGNC | UCSC Genome Browser View
View ORF sequence of this gene »

Vector Description	Vector Type	Price
Human HLA-DMB expression regular plasmid vector	Mammalian Gene Expression Vector Guide	From $189
Human HLA-DMB expression lentivirus vector	Mammalian Gene Expression Lentiviral Vector Guide	From $189
Human HLA-DMB expression adenovirus vector	Mammalian Gene Expression Adenoviral Vector Guide	From $189
Human HLA-DMB expression AAV vector	Mammalian Gene Expression AAV Vector Guide	From $189
Human HLA-DMB expression PiggyBac vector	Mammalian Gene Expression PiggyBac Vector Guide	From $189

Vector Description	Vector Type	Price
Human HLA-DMB shRNA lentivirus vector	Mammalian shRNA Knockdown Lentiviral Vector Guide	$149	View Vector
Human HLA-DMB shRNA adenovirus vector	Mammalian shRNA Knockdown Adenoviral Vector Guide	$299	View Vector
Human HLA-DMB shRNA AAV vector	Mammalian shRNA Knockdown AAV Vector Guide	$149	View Vector
Human HLA-DMB shRNA PiggyBac vector	Mammalian shRNA Knockdown PiggyBac Vector Guide	$149	View Vector

Vector Description	Vector Type	Price
Human HLA-DMB CRISPR regular plasmid vector	Mammalian CRISPR Vector (Single gRNA) Guide	$149	View Vector
Human HLA-DMB CRISPR lentivirus vector	Mammalian CRISPR Lentiviral Vector (Single gRNA) Guide	$149	View Vector
Human HLA-DMB CRISPR adenovirus vector	Mammalian CRISPR Adenoviral Vector (Single gRNA) Guide	$299	View Vector

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