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  3. Vectors for Zebrafish selenon

Vectors for Zebrafish selenon

Gene Information

  • Offical Gene Symbol selenon
  • Species Zebrafish (Danio rerio)
  • Offical Full Name selenoprotein N
  • Other Aliases SePN; cb686; selN; sepn1; wu:fb06g01; wu:fb73d02; wu:fv41b08; zgc:101091
  • Other Desigations selenoprotein N; selenoprotein N, 1
  • Gene Type protein-coding
  • 개요
    This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Inhibition of this gene in zebrafish also showed the importance of this gene in muscle organization during early development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3\' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. [provided by RefSeq, Aug 2017]
  • NCBI Gene ID 352914
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Zebrafish selenon(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Zebrafish selenon expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Zebrafish selenon expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Zebrafish selenon expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Zebrafish selenon expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Zebrafish selenon expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189

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