1. 홈
  2. 벡터 검색하기
  3. Vectors for Zebrafish dio3a

Vectors for Zebrafish dio3a

Gene Information

  • Offical Gene Symbol dio3a
  • Species Zebrafish (Danio rerio)
  • Offical Full Name iodothyronine deiodinase 3a
  • Other Aliases -
  • Other Desigations iodothyronine deiodinase 3a; deiodinase, iodothyronine, type IIIa
  • Gene Type protein-coding
  • 개요
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3\',5-triiodothyronine (T3) to inactive metabolites, 3,3\',5\'-triiodothyronine (RT3) and 3,3\'-diiodothyronine (T2), respectively. Two paralogs of this gene have been identified in zebrafish on chromosomes 17 and 20. Both encode enzymatically active proteins; however, their gene structure and tissue expression patterns are markedly different. This gene is intronless, like orthologs in all other vertebrate species studied to date, but unlike the paralog on chromosome 20, which is 2-exon. Knockdown of this gene indicates that it is essential for normal zebrafish embryonic and early larval development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3\' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2017]
  • NCBI Gene ID 100538339
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Zebrafish dio3a(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Zebrafish dio3a expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Zebrafish dio3a expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Zebrafish dio3a expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Zebrafish dio3a expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Zebrafish dio3a expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189

Can’t find desired vectors above? Use options below to obtain custom vectors.

나의 벡터 디자인하기

Use this option to design your vector using our online platform.

You can request cloning & virus packaging services for your vector here.

디자인 서포트 의뢰하기

Use this option to ask our scientists to design your vector for free.

You can also submit other service inquires here, including:

  • 바이러스 패키징
  • CRISPR targeting
  • BAC modification
  • Library construction
  • Plasmid DNA Preparation
  • RNA preparation
  • Mutagenesis
  • and more...