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  3. Vectors for Human TYROBP

Vectors for Human TYROBP

Gene Information

  • Offical Gene Symbol TYROBP
  • Species Human (Homo sapiens)
  • Offical Full Name transmembrane immune signaling adaptor TYROBP
  • Other Aliases DAP12; KARAP; PLOSL; PLOSL1
  • Other Desigations TYRO protein tyrosine kinase-binding protein; DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; TYRO protein tyrosine kinase binding protein; killer-activating receptor-associated protein; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
  • Gene Type protein-coding
  • 개요
    This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
  • NCBI Gene ID 7305
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human TYROBP(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human TYROBP expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human TYROBP expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human TYROBP expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human TYROBP expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human TYROBP expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human TYROBP shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human TYROBP shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Human TYROBP shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Human TYROBP shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human TYROBP CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human TYROBP CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Human TYROBP CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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