Human CFTR 벡터 - 렌티바이러스, AAV, shRNA & CRISPR I 벡터빌더

Gene Information

Offical Gene Symbol CFTR
Species Human (Homo sapiens)
Offical Full Name CF transmembrane conductance regulator
Other Aliases ABC35; ABCC7; CF; CFTR/MRP; MRP7; TNR-CFTR; dJ760C5.1
Other Desigations cystic fibrosis transmembrane conductance regulator; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Type protein-coding
개요
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]
NCBI Gene ID 1080
RefSeq Transcript
NM_000492.4
RefSeq Protein
NP_000483.3
External Links NCBI | OMIM | Ensembl | HGNC | UCSC Genome Browser View
View ORF sequence of this gene »

Vector Description	Vector Type	Price
Human CFTR expression regular plasmid vector	Mammalian Gene Expression Vector Guide	From $189
Human CFTR expression lentivirus vector	Mammalian Gene Expression Lentiviral Vector Guide	From $189
Human CFTR expression adenovirus vector	Mammalian Gene Expression Adenoviral Vector Guide	From $189
Human CFTR expression AAV vector	Mammalian Gene Expression AAV Vector Guide	From $189
Human CFTR expression PiggyBac vector	Mammalian Gene Expression PiggyBac Vector Guide	From $189

Vector Description	Vector Type	Price
Human CFTR shRNA lentivirus vector	Mammalian shRNA Knockdown Lentiviral Vector Guide	$149	View Vector
Human CFTR shRNA adenovirus vector	Mammalian shRNA Knockdown Adenoviral Vector Guide	$299	View Vector
Human CFTR shRNA AAV vector	Mammalian shRNA Knockdown AAV Vector Guide	$149	View Vector
Human CFTR shRNA PiggyBac vector	Mammalian shRNA Knockdown PiggyBac Vector Guide	$149	View Vector

Vector Description	Vector Type	Price
Human CFTR CRISPR regular plasmid vector	Mammalian CRISPR Vector (Single gRNA) Guide	$149	View Vector
Human CFTR CRISPR lentivirus vector	Mammalian CRISPR Lentiviral Vector (Single gRNA) Guide	$149	View Vector
Human CFTR CRISPR adenovirus vector	Mammalian CRISPR Adenoviral Vector (Single gRNA) Guide	$299	View Vector

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