Vectors for Human ABCB1

Gene Information

  • Offical Gene Symbol ABCB1
  • Species Human (Homo sapiens)
  • Offical Full Name ATP binding cassette subfamily B member 1
  • Other Aliases ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1; p-170
  • Other Desigations ATP-dependent translocase ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance; multidrug resistance protein 1; phospholipid transporter ABCB1
  • Gene Type protein-coding
  • 개요
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
  • NCBI Gene ID 5243
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human ABCB1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ABCB1 expression 일반 plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human ABCB1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human ABCB1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human ABCB1 expression 아데노부속바이러스 (AAV) vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human ABCB1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ABCB1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human ABCB1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human ABCB1 shRNA 아데노부속바이러스 (AAV) vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human ABCB1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ABCB1 CRISPR 일반 plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human ABCB1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human ABCB1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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