Vectors for Human SMAD2

Gene Information

  • Offical Gene Symbol SMAD2
  • Species Human (Homo sapiens)
  • Offical Full Name SMAD family member 2
  • Other Aliases CHTD8; JV18; JV18-1; LDS6; MADH2; MADR2; hMAD-2; hSMAD2
  • Other Desigations mothers against decapentaplegic homolog 2; MAD homolog 2; SMAD, mothers against DPP homolog 2; Sma- and Mad-related protein 2; mother against DPP homolog 2
  • Gene Type protein-coding
  • 개요
    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \'mothers against decapentaplegic\' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
  • NCBI Gene ID 4087
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human SMAD2(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human SMAD2 expression 일반 plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human SMAD2 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human SMAD2 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human SMAD2 expression 아데노부속바이러스 (AAV) vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human SMAD2 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human SMAD2 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
View Vector 
Human SMAD2 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $269
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Human SMAD2 shRNA 아데노부속바이러스 (AAV) vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
View Vector 
Human SMAD2 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human SMAD2 CRISPR 일반 plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
View Vector 
Human SMAD2 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human SMAD2 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $269
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