Vectors for Human LOC109433677

This region encompasses multiple alternative promoters of the bone morphogenetic protein 4 gene. These promoters are stimulated by binding of GLI family zinc finger proteins and NK2 homeobox 1. Activity of this region is downregulated by tumor necrosis factor, which may prevent association of Sp1 transcription factor to discrete recognition sites. The most proximal promoter may be regulated through competition between Sry-box 2, which represses activity, and long non-coding RNA maternally expressed 3. This locus also includes four accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]