Vectors for Human LOC109433677

Gene Information

  • Offical Gene Symbol LOC109433677
  • Species Human (Homo sapiens)
  • Offical Full Name -
  • Other Aliases -
  • Other Desigations ATAC-STARR-seq lymphoblastoid silent region 5757; ATAC-STARR-seq lymphoblastoid silent region 5758; ATAC-STARR-seq lymphoblastoid silent region 5759; ATAC-STARR-seq lymphoblastoid silent region 5760
  • Gene Type biological-region
  • 개요
    This region encompasses multiple alternative promoters of the bone morphogenetic protein 4 gene. These promoters are stimulated by binding of GLI family zinc finger proteins and NK2 homeobox 1. Activity of this region is downregulated by tumor necrosis factor, which may prevent association of Sp1 transcription factor to discrete recognition sites. The most proximal promoter may be regulated through competition between Sry-box 2, which represses activity, and long non-coding RNA maternally expressed 3. This locus also includes four accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
  • NCBI Gene ID 109433677
  • External Links NCBI UCSC Genome Browser View
No vectors are found in our database for this gene. We may introduce vectors for this gene in the future.

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