Vectors for Human LOC109279247

Gene Information

  • Offical Gene Symbol LOC109279247
  • Species Human (Homo sapiens)
  • Offical Full Name -
  • Other Aliases -
  • Other Desigations CRISPRi-FlowFISH-validated FUT1 regulatory element
  • Gene Type biological-region
  • 개요
    This region encompasses the bi-directional promoter of the FGF21 (fibroblast growth factor 21) and FUT1 (fucosyltransferase 1) genes on chromosome 19. Transcription of FGF21 is stimulated by ER stress and retinoic acid, and is mediated through association of activating transcription factor 4 (ATF4) with multiple recognition sites in this region. FUT1 is regulated by binding of Jun proto-oncogene (also known as c-Jun or AP-1 transcription factor subunit) to a distal recognition site in an intron of FGF21. A subregion was validated as a positively-acting cis-regulatory element for FUT1 based on CRISPR/Cas9-mediated perturbation (CRISPRi-FlowFISH method) in K562 cells. Two subregions marked by the H3K27ac and H3K4me1 histone modifications were also validated as active enhancers by ChIP-STARR-seq in primed human embryonic stem cells. [provided by RefSeq, Nov 2022]
  • NCBI Gene ID 109279247
  • External Links NCBI UCSC Genome Browser View
No vectors are found in our database for this gene. We may introduce vectors for this gene in the future.

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