Vectors for Human LOC108942766

Gene Information

  • Offical Gene Symbol LOC108942766
  • Species Human (Homo sapiens)
  • Offical Full Name -
  • Other Aliases -
  • Other Desigations OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:7940221-7940910
  • Gene Type biological-region
  • 개요
    This region represents the proximal promoter, a potential upstream promoter, and associated 5\' regulatory regions of the Nanog homeobox gene. These sequences include DNase I hypersensitive sites and multiple highly conserved regions, including a short conserved motif that is predicted to bind to POU class homeobox and SRY-box containing proteins (Oct/Sox box). Activity of this promoter region is stimulated by Wnt/beta catenin, transforming growth factor beta, hypoxia, and androgen/androgen receptor, and may be inhibited by protein kinase C. This region may be epigenetically silenced by DNA cytosine methylation during differentiation. A subregion was also shown to be an enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells, where it associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
  • NCBI Gene ID 108942766
  • External Links NCBI UCSC Genome Browser View
No vectors are found in our database for this gene. We may introduce vectors for this gene in the future.

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