Vectors for Human LOC108281177

Gene Information

  • Offical Gene Symbol LOC108281177
  • Species Human (Homo sapiens)
  • Offical Full Name -
  • Other Aliases SRR1
  • Other Desigations SOX2 gene-proximal regulation region; SOX2 regulatory region 1; Sharpr-MPRA regulatory region 720
  • Gene Type biological-region
  • 개요
    This region encompasses the 5\' regulatory region of SOX2 (SRY-box 2) and includes the proximal promoter and SOX2 regulatory region 1 (SRR1), which is a conserved enhancer. This sequence is positively regulated by binding of high mobility group AT-hook 1 and 2 and NK6 homeobox 3, and may be suppressed by msh homeobox 2, Y-box binding protein 1, and the polycomb complex. This promoter may be methylated and silenced in tumor cells. Four subregions were validated as active enhancers by ChIP-STARR-seq in human embryonic stem cells, where three are associated with the OCT4 and/or NANOG transcription factors, and three are marked by the H3K27ac and H3K4me1 histone modifications. A subregion of the SRR1 sequence was also validated as a functional repressive element by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Repressive non-DNase unmatched - State 22:ReprW, weaker Polycomb repression). [provided by RefSeq, Oct 2022]
  • NCBI Gene ID 108281177
  • External Links NCBI UCSC Genome Browser View
No vectors are found in our database for this gene. We may introduce vectors for this gene in the future.

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