Vectors for Human FEN1

Gene Information

  • Offical Gene Symbol FEN1
  • Species Human (Homo sapiens)
  • Offical Full Name flap structure-specific endonuclease 1
  • Other Aliases FEN-1; MF1; RAD2
  • Other Desigations flap endonuclease 1; DNase IV; maturation factor-1
  • Gene Type protein-coding
  • 개요
    The protein encoded by this gene removes 5\' overhanging flaps in DNA repair and processes the 5\' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5\' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
  • NCBI Gene ID 2237
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human FEN1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human FEN1 expression 일반 plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human FEN1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human FEN1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human FEN1 expression 아데노부속바이러스 (AAV) vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human FEN1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human FEN1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
View Vector 
Human FEN1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $259
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Human FEN1 shRNA 아데노부속바이러스 (AAV) vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
View Vector 
Human FEN1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human FEN1 CRISPR 일반 plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
View Vector 
Human FEN1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human FEN1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $259
View Vector 

Can’t find desired vectors above? Use options below to obtain custom vectors.

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